Technology Platforms
Peptide Modification Platforms
Labeling Engineering
By introducing tracer groups (such as fluorescent groups, biotin, radioisotopes) into peptides, functions such as tracking, detection, or targeting verification can be achieved.
PEGylated Peptides
PEGylation optimizes the pharmacokinetic properties of peptides (e.g., extending half-life and reducing immunogenicity).
Conjugation Technology
Peptide Conjugation Services（P-Drug Conjugate）
Three-element architecture of the targeted therapy system：
Targeting Peptide: Specifically binds to receptors/antigens on the surface of diseased cells (such as cancer cells);
Linker: Bridges the peptide and the drug, regulating drug release (cleavable/non-cleavable design);
Drug Payload: Delivers cytotoxins or therapeutic components (such as chemotherapeutic drugs, radionuclides).
Cyclization Modification
Diversified cyclization strategies: Construct disulfide bonds/alkylation/single-sulfur bonds/lactam bridges, etc.
Thioether Bonds: Stabilize the conformation of linear peptides through a single thioether bond. Disulfide Bonds: Two sulfur atoms covalently connect cysteine residues, significantly enhancing peptide rigidity.
Trisulfide Bonds: Uncommon, forming a more complex topological structure through the connection of three sulfur atoms.
Alkylation: Based on alkyl groups, carbon - carbon bonds or carbon - heteroatom bonds (such as C - N, C - O) are constructed.
Lactam Bridges: A closed-loop structure is formed by the condensation of carboxyl and amino groups within the peptide chain to form amide bonds.
